Correlation Among BMI, Fasting Plasma Glucose and HbA1c Levels in Subjects with Glycemic Anomalies Visiting Diabetic Clinics of Lahore

This study was aimed at determining correlations among body mass index (BMI), fasting plasma glucose (FPG) and HbA1c levels in glycemic anomalies in local population. A total number of 508 subjects (males 228, females 280) of age between 27–87 years with glycemic anomalies visiting Amin Memorial Trust Hospital (diabetic clinic) of Lahore were included in the study. Of the people identified with diabetes type 2 and impaired glucose tolerance (IGT) 58% were not previously diagnosed. The subjects ware divided into two different categories on the basis of fasting plasma glucose level and oral glucose tolerance test (OGTT), viz., 130 IGT subjects and 378 Diabetes mellitus type 2 subjects using Diabetes Expert Committee criteria of 2003. The OGTT diagnosed IGT subjects constituted were 65% and OGTT diagnosed diabetic subjects were 30%. In IGT subjects 22.3% subjects had normal HbA1c (5-6%), while 55% subjects had elevated HbA1c (6-8%) and 22.6% subjects had poor glycemic control with HbA1c > 8%. In diabetic subjects 29.1% subjects had HbA1c 6-8%, 63.3% diabetic subjects had 8-10% hemoglobin, while 7.6% diabetic subjects had HbA1c 10-18%. In IGT subjects 10% had normal BMI, 30% were overweight and 60% were obese. Among diabetic subjects 14% had normal weight, while 16% were overweight and 70% subjects were obese. A positive and highly significant correlation was observed with HbA1c in IGT and diabetics (r = 0.298, r = 0.460). In multiple regression analysis HbA1c was important predictor of FPG both in IGT and